hereditary disease split hand-foot malformation https://github.com/monarch-initiative/mondo/issues/6751 https://github.com/monarch-initiative/mondo/issues/6876 https://github.com/monarch-initiative/mondo/issues/6877 https://www.malacards.org/card/isolated_split_hand_split_foot_malformation https://www.malacards.org/card/split_hand_foot_malformation_8 DOID:0090020 OMIMPS:183600 split hand foot malformation MONDO:0016576 SCTID:81208006 NORD:1731 GARD:0006319 split-hand/foot malformation FEWER digits ectrodactyly MEDGEN:78566 SHFM Split Hand/Split Foot Malformation NCIT:C75000 Split hand-split foot malformation (SHFM) refers to a spectrum of genetically and clinically heterogenous terminal limb defect characterized by hypoplasia/ absence of central rays of the hands and feet (that can occur in one to all four digits), median clefts of the hands and/ or feet, aplasia and syndactyly, with a wide range of severity ranging from malformed central finger/ toe to a lobster claw-like appearance of the hands and feet. SHFM can be an isolated malformation or can be a feature in various syndromes (ADULT syndrome, EEC syndrome). SHFM usually follows an autosomal dominant pattern of inheritance with incomplete penetrance, but autosomal recessive and rarely X-linked inheritance have also been reported. Orphanet:2440 UMLS:C0265554 dysostosis