citrin deficiency citrullinemia type II CTLN2 NANDO:1200980 UMLS:C1863844 adult-onset type II citrullinemia adult-onset citrin deficiency GARD:0010215 MONDO:0016603 Orphanet:247585 citrullinemia type II SCTID:716863007 adult-onset type 2 citrullinemia citrullinemia type 2 MEDGEN:350276 NCIT:C150603 Citrullinemia type II is a severe subtype of citrin deficiency characterized clinically by adult onset (20 and 50 years of age), recurrent episodes of hyperammonemia and associated neuropsychiatric symptoms such as nocturnal delirium, confusion, restlessness, disorientation, drowsiness, memory loss, abnormal behavior (aggression, irritability, and hyperactivity), seizures, and coma.