hereditary disease frontonasal dysplasia https://github.com/monarch-initiative/mondo/issues/6877 MESH:C538065 UMLS:C1876203 MEDGEN:406292 icd11.foundation:782645776 DOID:0081044 NORD:1165 OMIMPS:136760 median cleft syndrome MONDO:0016643 median cleft face syndrome FND1 Orphanet:250 A group of rare bone development disorders characterized by an array of abnormalities affecting the eyes, forehead, and nose, and linked to midfacial dysraphia. The clinical picture is highly variable, but the major findings include hypertelorism, a broad nasal root, a large and bifid nasal tip, and widow's peak. Occasionally, abnormalities can include accessory nasal tags, cleft lip, ocular abnormalities (coloboma, cataract, microphthalmia), conductive hearing loss, basal encephalocele and/or agenesis of the corpus callosum. Intellectual deficit is rare and more likely to occur in cases where hypertelorism is severe or where there is extra-cranial involvement. GARD:0002392 frontonasal dysplasia 1 SCTID:86610004 dysostosis