syndromic disease sickle cell disease sickle cell-hemoglobin c disease syndrome https://github.com/monarch-initiative/mondo/issues/6746 https://www.malacards.org/card/sickle_cell_hemoglobin_c_disease_syndrome MedDRA:10057072 UMLS:C0019034 HbSC disease MEDGEN:5496 Orphanet:251365 A rare, genetic hemoglobinopathy characterized by anemia, reticulocytosis and erythrocyte abnormalities including target cells, irreversibly sickled cells and crystal-containing cells. Clinical course is similar to sickle cell disease, but less severe and with less complications. Signs and symptoms may include acute episodes of pain, splenic infarction and splenic sequestration crisis, acute chest syndrome, focal segmental glomerulosclerosis, ischemic brain injury, peripheral retinopathy, and osteonecrosis. sickle cell - hemoglobin C disease MONDO:0016669 sickle cell - haemoglobin C disease GARD:0006584