has characteristic has characteristic high grade astrocytic tumor anaplastic astrocytoma https://www.malacards.org/card/anaplastic_astrocytoma MEDGEN:137784 NANDO:2200086 grade III astrocytoma grade III astrocytic tumor Orphanet:251589 EFO:0002499 MedDRA:10060971 malignant astrocytoma MONDO:0016684 grade III astrocytic neoplasm DOID:3078 Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord. NCIT:C9477 ICDO:9401/3 ONCOTREE:AASTR GARD:0005860 UMLS:C0334579 NORD:769 anaplastic astrocytoma MedDRA:10002224 grade III astrocytic tumour astrocytoma, anaplastic, malignant astrocytoma (excluding glioblastoma) anaplastic cancer anaplastic