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    <!-- http://purl.obolibrary.org/obo/MONDO_0016685 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0016685">
        <rdfs:label>low-grade astrocytoma</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/MONDO_0016686 -->

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        <rdfs:label>diffuse astrocytoma</rdfs:label>
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        <oboInOwl:hasRelatedSynonym>fibrillary astrocytoma (histologic variant)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>low-grade diffuse astrocytoma</oboInOwl:hasRelatedSynonym>
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        <oboInOwl:hasExactSynonym>astrocytoma, diffuse, malignant</oboInOwl:hasExactSynonym>
        <ns3:IAO_0000115>A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified.</ns3:IAO_0000115>
        <oboInOwl:hasExactSynonym>WHO grade II astrocytoma</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>protoplasmic astrocytoma (histologic variant)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>MONDO:0016686</oboInOwl:id>
        <oboInOwl:hasExactSynonym>diffuse astrocytoma</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>GARD:0005907</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>grade II astrocytic tumor</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>grade II astrocytoma</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>Orphanet:251595</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>astrocytoma, diffuse</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MEDGEN:83708</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>UMLS:C0280785</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>grade II astrocytic neoplasm</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>DOID:4857</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>grade II astrocytic tumour</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>gemistocytic astrocytoma (histologic variant)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>NANDO:2200085</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ONCOTREE:DASTR</oboInOwl:hasDbXref>
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    <!-- http://purl.obolibrary.org/obo/MONDO_0021639 -->

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        <rdfs:label>grade II glioma</rdfs:label>
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