tumor of meninges diffuse leptomeningeal melanocytosis https://github.com/monarch-initiative/mondo/issues/6739 https://github.com/monarch-initiative/mondo/issues/6752 https://www.malacards.org/card/diffuse_leptomeningeal_melanocytosis UMLS:C4749348 Orphanet:252031 MONDO:0016745 GARD:0020739 Diffuse leptomeningeal melanocytosis is a rare tumor of meninges arising from leptomeningeal melanocytes, characterized by diffuse infiltration of the leptomeninges (pia mater and arachnoidea) anywhere in the central nervous system. Clinical features may include stillbirth, intracranial hypertension and hydrocephalus, seizure, ataxia, syringomyelia, cranial nerve palsy, intracranial hemorrhage, sphincter dysfunction and neuropsychiatric symptoms. Transformation into malignant melanoma of the central nervous system was reported. It may be associated with congenital nevi, as a part of neurocutaneous melanosis. DLM MEDGEN:1651380 leptomeningeal melanomatosis