rheumatic disorder myalgia-eosinophilia syndrome associated with tryptophan https://www.malacards.org/card/myalgia_eosinophilia_syndrome_associated_with_tryptophan A rare systemic disease characterized by severe myalgia and peripheral eosinophilia associated with tryptophan dietary supplementation. The symptoms do not subside after tryptophan discontinuation. Clinical presentation includes muscle tenderness and cramps, fatigue, weakness, paresthesia, peripheral edema, arthralgia, dyspnea, skin rash, dry mouth, and development of scleroderma-like skin abnormalities. MEDGEN:698358 UMLS:C1275050 Orphanet:2582 GARD:0018775 MedDRA:10014952 MONDO:0016822