primary tethered cord syndrome https://www.malacards.org/card/primary_tethered_cord_syndrome occult spinal dysraphism GARD:0004018 segmental vertebral anomalies SCTID:70534000 Tethered Cord Syndrome tethered cord syndrome occult spinal dysraphism sequence MONDO:0017086 Primary tethered cord syndrome is a genetic, non-syndromic congenital malformation of the neurenteric canal, spinal cord and column characterized by progressive neurologic deterioration (pain, sensorimotor deficits, abnormal gait, decreased tone or abnormal reflexes), musculoskeletal changes (foot deformities and asymmetry, muscle atrophy, limb weakness and numbness, gait disturbances, scoliosis) and/or genitourinary manifestations (bladder and bowel dysfunction). Midline cutaneous stigmata in the lumbosacral region, such as turfs of hair, skin appendages, dimples, subcutaneous lipomas, skin discoloration or hemangiomas, are frequently associated. Orphanet:268861 MEDGEN:1636724 UMLS:C4708602 icd11.foundation:66705662 NORD:1762 primary tethered spinal cord syndrome neural tube defect