syndromic disease arthrogryposis multiplex congenita 2, neurogenic type developmental anomaly of metabolic origin arthrogryposis-renal dysfunction-cholestasis syndrome https://github.com/monarch-initiative/mondo/issues/6749 arthrogryposis renal dysfunction cholestasis syndrome Arthrogryposis-Renal dysfunction-Cholestasis (ARC) syndrome is a multisystem disorder, characterized by neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with low serum gamma-glutamyl transferase activity. MONDO:0017123 Orphanet:2697 OMIMPS:208085 DOID:0050763 MESH:C535382 MEDGEN:1647210 UMLS:C4551984 ARC syndrome arthrogryposis, renal dysfunction, and cholestasis GARD:0000794 SCTID:720513002 arthrogryposis - renal dysfunction - cholestasis This term's classification was reviewed in the context of the Strategic Refinement project (2023) and was determined to be excluded from the 'integumentary system disorder' (MONDO:0002051) ontology branch (https://orcid.org/0000-0001-9310-0163, https://orcid.org/0000-0003-4830-7530) arthrogryposis multiplex congenita, renal dysfunction, and cholestasis inborn disorder of bilirubin metabolism