disease arises from feature disease has basis in feature disease has feature Frontotemporal dementia movement disorder neurodegenerative disease hereditary dementia frontotemporal dementia with motor neuron disease frontotemporal dementia with amyotrophic lateral sclerosis Orphanet:275872 GARD:0017273 FTDALS frontotemporal dementia with ALS FTD-MND MESH:C566288 MEDGEN:854771 OMIMPS:105550 FTD-ALS UMLS:C3888102 MONDO:0017161 icd11.foundation:1171850356 Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual impairment, emotional disorders and transcortical motor aphasia that eventually leads to mutism, in addition to the manifestations of motor neuron disease such as neurogenic muscular wasting (similar to what is seen in amyotrophic lateral sclerosis). The disease is progressive, with death occurring 2-5 years after onset. inherited neurodegenerative disorder