disease has feature Reduced bone mineral density syndromic disease osteoporosis-macrocephaly-blindness-joint hyperlaxity syndrome SCTID:716189005 Heide syndrome Orphanet:2787 GARD:0018778 MONDO:0017199 Osteoporosis-macrocephaly-blindness-joint hyperlaxity syndrome is characterized by osteoporosis, macrocephalus, brachytelephalangy, and hyperextensibility of the joints. Congenital amaurosis and intellectual deficit have also been reported. This syndrome has been described in three members of one family. obsolete primary bone dysplasia with decreased bone density