has_onset_before has_onset_during_or_after 20-year-old stage 50-year-old stage Parkinson disease primary orthostatic hypotension young-onset Parkinson disease https://www.malacards.org/card/early_onset_parkinsons_disease YOPD UMLS:C4275179 A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms. MONDO:0017279 GARD:0016610 DOID:0060894 early-onset Parkinson disease early-onset Parkinson's disease Orphanet:2828 SCTID:715345007 MEDGEN:907947