vascular disorder Marfan syndrome neonatal Marfan syndrome https://www.malacards.org/card/neonatal_marfan_syndrome GARD:0021128 SCTID:763839005 icd11.foundation:1102890898 MONDO:0017309 neonatal MFS UMLS:C4016054 MEDGEN:864491 Orphanet:284979 Neonatal Marfan syndrome is a rare, severe and life-threatening genetic disease, occurring during the neonatal period, characterized by classical Marfan syndrome manifestations in addition to facial dysmorphism (megalocornea, iridodonesis, ectopia lentis, crumpled ears, loose redundant skin giving a 'senile' facial appearance), flexion joint contractures, pulmonary emphysema, and a severe, rapidly progressive cardiovascular disease (including ascending aortic dilatation and severe mitral and/or tricuspid valve insufficiency). Additionally, skeletal manifestations (arachnodactyly, dolichostenomelia, pectus deformities) are also associated.