disease has location disease has feature plasma cell type IV hypersensitivity disease leukocyte disorder plasma cell neoplasm acquired peripheral neuropathy POEMS syndrome https://www.malacards.org/card/poems_syndrome NORD:1586 Orphanet:2905 Takatsuki syndrome POEMS syndrome is associated with plasmacytomas and osteosclerotic lesions. The etiologic factors of this constellation of diseases are not well defined, but radiation therapy to localized lesions is often of benefit, and there is a report that autologous hematopoetic cell transplantation benefited a patient with refractory disease. SCTID:79268002 MESH:D016878 POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels. NANDO:1200033 POEMS syndrome Crow-Fukase syndrome MONDO:0017364 PEP syndrome polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome DOID:14039 NCIT:C80303 osteosclerotic myeloma MEDGEN:39276 MedDRA:10053869 icd11.foundation:1555299114 polyneuropathy organomegaly EFO:1001115 GARD:0007411 polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome UMLS:C0085404 paraneoplastic neurologic syndrome parneoplastic endocrine syndrome paraneoplastic hematological syndrome