endocrine system disorder rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome https://www.malacards.org/card/rapid_onset_childhood_obesity_hypothalamic_dysfunction_hypoventilation_autonomic_dysregulation_syndrome rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation-neural tumors syndrome NCIT:C121944 Rapid-onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Orphanet:293987 MONDO:0017408 rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome NORD:1648 A very rare disorder that appears after the first year and a half of life in previously healthy children. It is characterized by rapid-onset weight gain, hypothalamic dysfunction, breathing abnormalities, and autonomic system dysregulation. The hypothalamic dysfunction manifestations include inability to maintain normal water balance, high prolactin levels, low thyroid, low cortisol, and early or late puberty. The breathing abnormalities include sleep apnea and alveolar hypoventilation, requiring ventilation support. The autonomic system dysregulation includes eye abnormalities, intestinal abnormalities, temperature dysregulation, and low heart rhythm. This disorder requires early recognition because it may lead to cardiorespiratory arrest. Up to 40% of the patients develop tumors of neural crest origin. GARD:0010407 ROHHAD rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation-neural tumours syndrome MEDGEN:1670711 UMLS:C4751121 rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation ROHHADNET ROHHAD syndrome