syndromic disease mirror polydactyly-vertebral segmentation-limbs defects syndrome https://www.malacards.org/card/mirror_polydactyly_vertebral_segmentation_limbs_defects_syndrome Mirror polydactyly-vertebral segmentation-limbs defects syndrome is characterized by mirror polydactyly, vertebral hypersegmentation and severe congenital limb deficiencies. Duodenal atresia and absent thymus were also reported. So far, it has been described in four unrelated infants identified through a congenital malformation screening program carried out in Spain. The prevalence was estimated at around 1 in 330,000. The etiology is unknown but it was suggested that the syndrome is caused by defective expression of a developmental control gene. UMLS:C4275100 Orphanet:3004 MEDGEN:904039 GARD:0018784 MONDO:0017583