segmental progressive overgrowth syndrome with fibroadipose hyperplasia https://github.com/monarch-initiative/mondo/issues/5210 https://github.com/monarch-initiative/mondo/issues/9285 https://www.malacards.org/card/segmental_progressive_overgrowth_syndrome_with_fibroadipose_hyperplasia Orphanet:314662 UMLS:C5192432 MONDO:0017812 MEDGEN:1673986 A rare PIK3CA-related overgrowth syndrome disease characterized by segmental and progressive overgrowth, predominantly involving the adipose tissue, or a mixture of adipose and fibrous tissue, with variable involvement of subcutaneous and muscular tissue, as well as skeletal overgrowth. Overgrowth severity and range is highly variable, although frequently it is asymmetric and disproportionate, it affects lower extremities more than the upper ones, and progresses in a distal to proximal patten. Congenital overgrowth is typically associated. GARD:0021384 PIK3CA-related overgrowth spectrum