coagulation protein disease hemorrhagic disease syndromic disease multiple sclerosis-ichthyosis-factor VIII deficiency syndrome https://github.com/monarch-initiative/mondo/issues/6749 https://github.com/monarch-initiative/mondo/issues/6878 https://www.malacards.org/card/multiple_sclerosis_ichthyosis_factor_viii_deficiency_syndrome MEDGEN:1391655 Orphanet:3151 GARD:0018787 UMLS:C4518551 Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome is characterized by the association of multiple sclerosis with lamellar ichthyosis and hematological anomalies (beta thalassemia minor and a quantitative deficit of factor VIII-von Willebrand complex). Other clinical manifestations may include eye involvement (optic atrophy, diplopia), neuromuscular involvement (ataxia, pyramidal syndrome, gait disturbance) and sensory disorder. There have been no further descriptions in the literature since 1992. MONDO:0017837