respiratory system disorder Siegler-Brewer-Carey syndrome https://rarediseases.info.nih.gov/diseases/4867/siegler-brewer-carey-syndrome https://www.malacards.org/card/siegler_brewer_carey_syndrome_2 UMLS:C2931473 SCTID:721076000 fatal multisystem syndrome involving the eyes, ears, lungs, intestines, and kidneys MONDO:0017849 MEDGEN:419088 GARD:0004867 MESH:C537335 Orphanet:3167 Siegler-Brewer-Carey syndrome is characterized by cataracts, otitis media, intestinal malabsorption, chronic respiratory infection, and failure to thrive. It has been recently described in two sibs born to consanguineous parents. The patients also developed recurrent pneumonia and progressive azotemia leading to end-stage renal disease. Both children died of overwhelming infection (sepsis, meningitis). An autosomal recessive mode of inheritance was proposed. Siegler Brewer Carey syndrome