primary cutaneous amyloidosis amyloidosis cutis dyschromia https://www.malacards.org/card/amyloidosis_primary_localized_cutaneous_3 GARD:0017466 Amyloidosis cutis dyschromia is a rare primary cutaneous amyloidosis characterized by macular or reticulate hyperpigmentation with symmetrically distributed guttate hypo- and hyperpigmented lesions which progress gradually over the years to involve almost the entire body (with relative sparing of the face, hands, feet and neck). Patients are usually asymptomatic, however mild pruritus may be associated. Amyloid deposition in the papillary dermis is observed on skin biopsy. Systemic amyloidosis is not present and association with generalized morphea, atypical Parkinsonism, spasticity, motor weakness or colon carcinoma is rare. MONDO:0017906 Orphanet:319635 MEDGEN:1641859 UMLS:C4554601 amyloidosis cutis dyschromica DOID:0080932