complex hereditary spastic paraplegia maternally-inherited spastic paraplegia https://www.malacards.org/card/maternally_inherited_spastic_paraplegia maternally-inherited SPG GARD:0021433 A rare, genetic, complex hereditary spastic paraplegia disorder characterized by adulthood-onset of slowly progressive, bilateral, mainly lower limb spasticity and distal weakness associated with lower limb pain, hyperreflexia, and reduced vibration sense. Axonal neuropathy is frequently observed on electromyography and nerve conduction examination. UMLS:C4755299 MEDGEN:1663227 MT-ATP6-related mitochondrial spastic paraplegia MONDO:0017917 Orphanet:320360