autosomal dominant complex spastic paraplegia spastic paraplegia-Paget disease of bone syndrome https://www.malacards.org/card/spastic_paraplegia_paget_disease_of_bone_syndrome Orphanet:329475 Spastic paraplegia-Paget disease of bone syndrome is an extremely rare, complex form of hereditary spastic paraplegia characterized by a slowly progressive spastic paraplegia (with increased muscle tone, decreased strength in the anterior tibial muscles and hyperreflexia in the lower extremities with Babinski sign) presenting in adulthood, associated with Paget disease of the bone. Cognitive decline, dementia and myopathic changes at muscle biopsy have not been reported. GARD:0021491 UMLS:C4511969 MONDO:0018005 MEDGEN:1388986 obsolete primary bone dysplasia with disorganized development of skeletal components