obsolete non-syndromic central nervous system malformation neural tube defect https://www.malacards.org/card/neural_tube_defects MESH:D009436 DOID:0080074 NCIT:C84923 MEDGEN:18009 A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida. ICD9:742.8 spinal dysraphism SCTID:253098009 UMLS:C0027794 GARD:0018796 MONDO:0018075 Orphanet:3388 NTD obsolete genetic nervous system disorder central nervous system malformation