disease has feature Hearing impairment Optic atrophy Diabetes mellitus syndromic disease type 1 diabetes mellitus Wolfram syndrome https://www.malacards.org/card/wolfram_syndrome DIDMOAD MONDO:0018105 diabetes insipidus, diabetes mellitus, optic atrophy, and deafness syndrome GARD:0007898 SCTID:70694009 NANDO:1200757 NCIT:C35133 Wolfram syndrome (WS) also known as DIDMOAD, is a neurodegenerative disorder characterized by type I diabetes mellitus (DM), diabetes insipidus (DI), sensorineural deafness (D), bilateral optical atrophy (OA) and neurological signs. Other related problems are urinary tract atony, ataxia, peripheral neuropathy, psychiatric disorders and/or seizures. 2 types of WS may be distinguished: type 1 and type 2 (WS1 and WS2). MEDGEN:21923 Orphanet:3463 UMLS:C0043207 Wolfram syndrome diabetes mellitus and insipidus with optic atrophy and deafness DIDMOAD syndrome icd11.foundation:151381747 MESH:D014929 DOID:10632 ICD9:250.80 diabetes insipidus-diabetes mellitus-optic atrophy-deafness syndrome