mouth disorder oral submucous fibrosis https://rarediseases.info.nih.gov/diseases/7264/oral-submucous-fibrosis https://www.malacards.org/card/oral_submucous_fibrosis MONDO:0018166 MESH:D009914 EFO:1001818 NCIT:C34866 GARD:0007264 UMLS:C0029172 ICD9:528.8 DOID:5773 oral cavity submucous fibrosis Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment. Orphanet:357154 SCTID:32883009 MEDGEN:45213 OSMF oral submucosal fibrosis, including of tongue icd11.foundation:1798376929 ICD10CM:K13.5 disorder of facial skeleton