acute myeloid leukemia with t(8;16)(p11;p13) translocation https://github.com/monarch-initiative/mondo/issues/8567 https://www.malacards.org/card/acute_myeloid_leukemia_with_kat6a_crebbp_fusion AML with t(8;16)(p11;p13) translocation SCTID:725390002 UMLS:C4511003 DOID:0070630 NCIT:C200421 GARD:0021588 A distinct form of Acute myeloid leukemia (AML) in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed. MEDGEN:1376688 Orphanet:370026 MONDO:0018256 acute myeloid leukemia