disease has basis in dysfunction of disease has basis in disruption of disease caused by disruption of disease disrupts disease causes disruption of immune system process superoxide-generating NAD(P)H oxidase activity NADPH oxidase complex hereditary disease inflammatory bowel disease phagocyte bactericidal dysfunction functional neutrophil defect chronic granulomatous disease https://rarediseases.info.nih.gov/diseases/6100/chronic-granulomatous-disease https://www.malacards.org/card/chronic_granulomatous_disease NANDO:1200357 CGD MEDGEN:5377 icd11.foundation:1329764681 UMLS:C0018203 chronic septic granulomatosis SCTID:387759001 MONDO:0018305 Orphanet:379 NORD:968 GARD:0006100 DOID:3265 granulomatous disease, chronic OMIMPS:306400 Chronic granulomatous disease (CGD) is a rare primary immunodeficiency, mainly affecting phagocytes, which is characterized by an increased susceptibility to severe and recurrent bacterial and fungal infections, along with the development of granulomas. MedDRA:10008906 NANDO:2200757 MESH:D006105 NCIT:C26788 inflammatory disease defective phagocytic cell engulfment