disease arises from feature disease has basis in feature megacolon hereditary disease Hirschsprung disease https://github.com/monarch-initiative/mondo/issues/9097 Hirschsprung's disease MONDO:0018309 NCIT:C34700 pelvirectal achalasia Hirschsprung disease aganglionic megacolon congenital megacolon NANDO:2200945 congenital intestinal aganglionosis icd11.foundation:1772690306 NANDO:2200948 ICD10CM:Q43.1 MedDRA:10010539 Orphanet:388 MESH:D006627 NANDO:1200903 SCTID:204739008 HSCR UMLS:C0019569 Hirschsprung disease (HSCR) is a congenital intestinal motility disorder that is characterized by signs of intestinal obstruction due to the presence of an aganglionic segment of variable extent in the terminal part of the colon. OMIMPS:142623 MEDGEN:5559 Hirschsprung disease susceptibility GARD:0006660 DOID:10487 NORD:1244 intestinal motility disease neurocristopathy