acute myeloid leukemia with inv3(p21;q26.2) or t(3;3)(p21;q26.2) https://github.com/monarch-initiative/mondo/issues/8567 https://rarediseases.info.nih.gov/diseases/12759/acute-myeloid-leukemia-with-inv3p21q262-or-t33p21q262 https://www.malacards.org/card/acute_myeloid_leukemia_with_inv3q21q262_or_t33q21q262 AML with inv3(q21;q26.2) or t(3;3)(q21;q26.2) GARD:0012759 Acute myeloid leukemia with inv(3)(q21;q26.2) or t(3;3)(q21;q26.2) is a subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts in the bone marrow, blood and, rarely, other tissues. Bone marrow typically shows small, hypolobated megakaryocytes and multilineage dyslplasia. Patients typically present with leukocytosis, anemia, variable platelet counts and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding, bruising, recurrent infections, bone pain) and/or extramedullary site involvement (gingivitis, splenomegaly). High resistance to conventional chemotherapy is reported. MONDO:0018435 UMLS:C2826172 Orphanet:402020 NCIT:C82426 acute myeloid leukaemia with inv3(q21;q26.2) or t(3;3)(q21;q26.2) AML with inv3(p21;q26.2) or t(3;3)(p21;q26.2) MEDGEN:415269 acute myeloid leukemia