megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) https://www.malacards.org/card/megakaryoblastic_acute_myeloid_leukemia_with_t122p13q13 Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) is a rare subtype of acute myeloid leukemia with recurrent cytogenetic abnormalities characterized by clonal proliferation of myeloid blasts with predominantly megakaryoblastic differentiation in the bone marrow and blood, often with extensive infiltration of the abdominal organs. It occurs typically in infants and usually presents with hepatosplenomegaly, anemia, thrombocytopenia and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections). Myelofibrosis and fibrosis of other infiltrated organs is also characteristic of this disease. SCTID:763796007 MEDGEN:1638466 Orphanet:402023 GARD:0021712 MONDO:0018436 UMLS:C4706584 megakaryoblastic AML with t(1;22)(p13;q13) acute myeloid leukemia