acute myeloid leukemia with NPM1 somatic mutations https://www.malacards.org/card/acute_myeloid_leukemia_with_npm1_somatic_mutations GARD:0021713 SCTID:763309005 Acute myeloid leukemia with NPM1 somatic mutations is a subtype of acute myeloid leukemia with recurrent genetic abnormalities characterized by clonal proliferation of myeloid blasts harboring mutations of the NPM1 gene in the bone marrow, blood and other tissues. It is associated with multilineage dysplasia, involving the myeloid, monocytic, erythroid, and megakaryocytic cell lineages. Patients usually present with leukocytosis, thrombocytosis and nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain), with frequent extramedullary involvement typically presenting as gingival hyperplasia and lymphadenopathy. Orphanet:402026 AML with NPM1 somatic mutations MONDO:0018437 UMLS:C4706386 MEDGEN:1633725 acute myeloid leukemia