has material basis in germline mutation in disease has basis in disruption of disease caused by disruption of disease has feature MAP3K14 canonical NF-kappaB signal transduction Decreased circulating immunoglobulin concentration Decreased total B cell count NIK deficiency https://www.malacards.org/card/nik_deficiency MAP3K14 non-severe combined immunodeficiency MEDGEN:1808868 UMLS:C5680065 GARD:0021864 A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14). MONDO:0018642 Orphanet:447731 primary immunodeficiency with multifaceted aberrant lymphoid immunity non-severe combined immunodeficiency caused by mutation in MAP3K14 non-SCID combined immunodeficiency