multiple sclerosis pediatric multiple sclerosis https://github.com/monarch-initiative/mondo/issues/6752 https://rarediseases.info.nih.gov/diseases/10443/pediatric-multiple-sclerosis https://www.malacards.org/card/pediatric_multiple_sclerosis MS paediatric Orphanet:477738 UMLS:C5568571 multiple sclerosis, paediatric MONDO:0018784 paediatric MS multiple sclerosis, pediatric MEDGEN:1799994 GARD:0010443 MS pediatric Pediatric multiple sclerosis (MS) is a rare multiple sclerosis variant characterized by the onset of multiple sclerosis (i.e. one or multiple episodes of clinical CNS symptoms consistent with acquired CNS demyelination, with radiologically proven dissemination of inflammatory lesions in space and time, following exclusion of other disorders) before the age of 18 years old. Pediatric MS patients present a predominantly relapsing-remitting course with first attack usually consisting of optic neuritis, transverse myelitis, acute disseminated encephalomyelitis and monofocal or polyfocal neurological deficits. A high burden of T2-hyperintense lesions on initial MRI, primarily of the supratentorial region and/or of the cervical spinal cord, has been reported. pediatric MS