<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/MONDO?iri=http://purl.obolibrary.org/obo/MONDO_0018872"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:skos="http://www.w3.org/2004/02/skos/core#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns2="http://purl.obolibrary.org/obo/mondo#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#ordo_disorder"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#gard_rare"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#otar"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#excluded_subClassOf"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#curated_content_resource"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000233"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#exactMatch"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#doid_rare"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#orphanet_rare"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#rare"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/mondo#nord_rare"/>
    <AnnotationProperty rdf:about="http://www.w3.org/2004/02/skos/core#closeMatch"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/MONDO_0011118 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0011118">
        <rdfs:label>bilineal acute myeloid leukemia</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/MONDO_0015667 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0015667">
        <rdfs:label>acute myeloid leukemia by FAB classification</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/MONDO_0018872 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/MONDO_0018872">
        <rdfs:label>acute megakaryoblastic leukemia</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/MONDO_0015667"/>
        <ns4:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/6490</ns4:IAO_0000233>
        <ns4:IAO_0000233 rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://github.com/monarch-initiative/mondo/issues/9097</ns4:IAO_0000233>
        <rdfs:seeAlso rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://rarediseases.info.nih.gov/diseases/524/acute-megakaryoblastic-leukemia</rdfs:seeAlso>
        <ns2:curated_content_resource rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://www.malacards.org/card/acute_megakaryocytic_leukemia</ns2:curated_content_resource>
        <oboInOwl:hasRelatedSynonym>acute myeloblastic leukaemia type 7</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>megakaryocytic leukaemia</oboInOwl:hasRelatedSynonym>
        <oboInOwl:id>MONDO:0018872</oboInOwl:id>
        <oboInOwl:hasDbXref>EFO:0003025</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ONCOTREE:AMKL</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>FAB M7</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>GARD:0000524</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Wikipedia:Acute_megakaryoblastic_leukemia</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MESH:D007947</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MEDGEN:44124</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute M7 myeloid leukemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute megakaryocytic leukemias</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute myeloid leukaemia M7</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>MedDRA:10060556</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>NANDO:2200011</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICDO:9910/3</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>ICD9:207.2</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>acute myeloblastic leukemia type 7</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>SCTID:277602003</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute megakaryoblastic leukaemia (FAB type M7)</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>DOID:8761</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>UMLS:C0023462</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>thrombocytic leukemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>ICD10CM:C94.2</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute megakaryoblastic leukemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>AML M7</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>NCIT:C3170</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>acute megakaryoblastic leukemia, FAB M7</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>icd11.foundation:2057381869</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>AMKL</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute M7 myeloid leukaemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute megakaryoblastic leukemia (FAB type M7)</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute megakaryocytic leukaemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute myeloid leukemia M7</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>leukemia, megakaryocytic, malignant</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>acute megakaryocytic leukemia</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>Orphanet:518</oboInOwl:hasDbXref>
        <skos:exactMatch rdf:resource="http://id.who.int/icd/entity/2057381869"/>
        <skos:closeMatch rdf:resource="http://identifiers.org/meddra/10060556"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/medgen/44124"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/mesh/D007947"/>
        <skos:exactMatch rdf:resource="http://identifiers.org/snomedct/277602003"/>
        <skos:exactMatch rdf:resource="http://linkedlifedata.com/resource/umls/id/C0023462"/>
        <skos:exactMatch rdf:resource="http://purl.bioontology.org/ontology/ICD10CM/C94.2"/>
        <skos:exactMatch rdf:resource="http://purl.obolibrary.org/obo/DOID_8761"/>
        <ns2:excluded_subClassOf rdf:resource="http://purl.obolibrary.org/obo/MONDO_0011118"/>
        <skos:exactMatch rdf:resource="http://purl.obolibrary.org/obo/NCIT_C3170"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#doid_rare"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#gard_rare"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#nord_rare"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#ordo_disorder"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#orphanet_rare"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#otar"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/mondo#rare"/>
        <skos:exactMatch rdf:resource="http://www.ebi.ac.uk/efo/EFO_0003025"/>
        <skos:exactMatch rdf:resource="http://www.orpha.net/ORDO/Orphanet_518"/>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



