autosomal dominant disease syndromic disease vascular disorder Marfan and Marfan-related disorder Loeys-Dietz syndrome https://www.malacards.org/card/loeys_dietz_syndrome UMLS:C2697932 Loeys-Dietz syndrome NCIT:C75006 aortic aneurysm syndrome, Loeys-Dietz type ICD9:759.89 aortic aneurysm syndrome due to TGF-beta receptors anomalies MESH:D055947 OMIMPS:609192 DOID:0050466 NORD:91173 Loeys-Dietz syndrome is a rare genetic connective tissue disorder characterized by a broad spectrum of craniofacial, vascular and skeletal manifestations with four genetic subtypes described forming a clinical continuum. SCTID:446263001 Orphanet:60030 MONDO:0018954 NANDO:2200969 GARD:0010788 MEDGEN:395827