islet cell adenomatosis familial hyperinsulinism congenital isolated hyperinsulinism https://www.malacards.org/card/congenital_isolated_hyperinsulinism Congenital Hyperinsulinism Orphanet:657 hyperinsulinism familial with pancreatic nesidioblastosis hypoglycemia hyperinsulinemic of infancy persistent hyperinsulinemic hypoglycemia of infancy GARD:0003947 chi Congenital isolated hyperinsulinism (CHI), a rare endocrine disease is the most frequent cause of severe and persistent hypoglycemia in the neonatal period and early infancy and is characterized by an excessive or uncontrolled insulin secretion (inappropriate for the level of glycemia) and recurrent episodes of profound hypoglycemia requiring rapid and intensive treatment to prevent neurological sequelae. CHI comprises 2 different forms: diazoxide-sensitive diffuse hyperinsulinism and diazoxide-resistant hyperinsulinism. congenital hyperinsulinism hyperinsulinemic hypoglycemia familial NORD:999 hyperinsulinism congenital PHHI NCIT:C122923 MONDO:0019010 overgrowth syndrome