multiple congenital anomalies/dysmorphic syndrome-intellectual disability obsolete branchial arch or oral-acral syndrome obsolete syndrome or malformation associated with head and neck malformations otopalatodigital syndrome spectrum disorder otopalatodigital syndrome SCTID:767130007 UMLS:C5779873 GARD:0007293 MEDGEN:1843451 A form of frontootopalatodigital syndrome, characterized by deafness, cleft palate, and characteristic digital anomalies. OPD syndrome is divided into two forms based on severity: the milder form designated OPD type 1 (OPD1), and the more severe and often lethal form designated OPD type 2 (OPD2). OPD is an X-linked disorder. Two other genetic disorders with features overlapping OPD, frontometaphyseal dysplasia (FMD) and osteodysplasty, Melnick-Needles type (MNS) have been described; thus OPD1, OPD2, FMD, and MNS are allelic disorders. oto-palatal-digital syndrome MONDO:0019027 icd11.foundation:1506946342 Orphanet:669 oto-palato-digital syndrome type 2 (Andre syndrome) X-linked syndromic intellectual disability