has material basis in germline mutation in MC4R obesity due to melanocortin 4 receptor deficiency https://www.malacards.org/card/obesity_due_to_melanocortin_4_receptor_deficiency Orphanet:71529 SCTID:717269008 Melanocortin 4 receptor (MC4R) deficiency is the commonest form of monogenic obesity identified so far. MC4R deficiency is characterized by severe obesity, an increase in lean body mass and bone mineral density, increased linear growth in early childhood, hyperphagia beginning in the first year of life and severe hyperinsulinaemia, in the presence of preserved reproductive function. NCIT:C120394 UMLS:C4273958 MEDGEN:903905 MC4R deficiency GARD:0016690 MONDO:0019115 inherited obesity