neurodegenerative disease primary progressive freezing gait https://www.malacards.org/card/primary_progressive_freezing_gait Primary progressive freezing gait is a rare, heterogeneous, progressively incapacitating neurodegenerative disease characterized by freezing of gait (usually during the first 3 years), later associating postural instability, eventually resulting in a wheelchair-bound state. Other features may include mild bradykinesia, rigidity, postural tremor, hyperreflexia, speech disorder and dementia. The disease is unresponsive to dopaminergic treatments. GARD:0018930 SCTID:715627004 MEDGEN:894846 PPFG UMLS:C4275078 MONDO:0019160 icd11.foundation:431694225 Orphanet:75567 parkinsonian disorder