autoimmune disease of ear, nose and throat lacrimal apparatus disorder IgG4-related ophthalmic disorder IgG4-related dacryoadenitis and sialadenitis https://rarediseases.info.nih.gov/diseases/7043/igg4-related-dacryoadenitis-and-sialadenitis https://www.malacards.org/card/mikulicz_disease SCTID:7826003 icd11.foundation:796087277 MONDO:0019191 MedDRA:10051457 UMLS:C0026103 IgG4-related dacryoadenitis and sialoadenitis (Mikulicz disease) is an IgG4-related sclerosing disease characterized by persistent, usually painless, bilateral enlargement of the lacrimal, parotid, and submandibular glands associated with elevated levels of serum immunoglobulin (Ig) G4 and with lymphocyte and IgG4-positive plasmacyte infiltration. It predominantly causes mouth and eye dryness but can also affect other organs such as the lungs, liver, and kidneys, and be accompanied by complications such as autoimmune pancreatitis (AIP), retroperitoneal fibrosis, and tubulointerstitial nephritis. MESH:D008882 MEDGEN:6399 GARD:0007043 Mikulicz syndrome (former) NANDO:1200929 Mikulicz's disease (former) MedDRA:10052317 DOID:12900 Mikulicz disease Mikulicz disease (former) NCIT:C34819 chronic dacryoadenitis and sialadenitis Orphanet:79078