epidermal disease ichthyosis https://github.com/monarch-initiative/mondo/issues/2114 https://github.com/monarch-initiative/mondo/pull/2110 https://www.malacards.org/card/ichthyosis MedDRA:10021198 ichthyosis (disease) Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed cell death known as cornification. Cornification leads to the formation of the outermost skin barrier, i.e. the cornified layer, as well as to the formation of hair and nails. (PMID:23792051) UMLS:C0020757 DOID:1697 NCIT:C84776 ichthyosis MONDO:0019269 DOC GARD:0018985 fish skin disease non-syndromic ichthyosis disorder of cornification Disorders of cornification that are characterized by visible scaling and/or hyperkeratosis of most or all of the skin. Inherited ichthyoses, defined as the generalized form of Mendelian disorders of cornification, affect most or all of the skin. This etiologically and phenotypically heterogenous group of conditions is caused by mutations in various different genes important for keratinocyte differentiation and epidermal barrier function. Acquired forms of ichthyosis can be observed with certain autoimmune, inflammatory, metabolic, endocrine, or infectious diseases or with malignancies. NANDO:1200618 MESH:D007057 HP:0008064 ichthyosis (disease) fish scale disease Orphanet:79354 MEDGEN:7002