disease has major feature Hypopigmentation of the skin disease skin pigmentation disorder hypopigmentation of the skin https://www.malacards.org/card/hypopigmentation_of_the_skin hypopigmentation of the skin (disease) UMLS:C0162835 A condition caused by a deficiency or a loss of melanin pigmentation in the epidermis, also known as hypomelanosis. Hypopigmentation can be localized or generalized, and may result from genetic defects, trauma, inflammation, or infections. Orphanet:79376 HP:0001010 hypopigmentation of the skin (disease) hypomelanoses hypomelanosis MedDRA:10040868 MEDGEN:102477 MONDO:0019290 MESH:D017496 hypopigmentation of the skin