disease has feature Scleroderma rheumatic disorder autoimmune disease scleroderma scleroderma (disease) Orphanet:801 DOID:419 EFO:1001993 UMLS:C0011644 scleroderma (disease) GARD:0018705 MedDRA:10039710 NCIT:C26746 MEDGEN:3770 Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc). scleroderma HP:0100324 MONDO:0019340