congenital nervous system disorder multiple congenital anomalies/dysmorphic syndrome-intellectual disability X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome https://github.com/monarch-initiative/mondo/issues/5588 https://www.malacards.org/card/x_linked_intellectual_disability_hypogammaglobulinemia_progressive_neurological_deterioration_syndrome UMLS:C4304919 MONDO:0019416 GARD:0019053 MEDGEN:930588 Orphanet:85317 X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome is characterized by moderate intellectual deficit, bilateral single palmar creases, seizures, variable hypogammaglobulinemia and characteristic features (synophrys, prognathism, and hirsutism). It has been reported in three males from two generations of one family. All underwent progressive neurological deterioration. This syndrome is transmitted as an X-linked trait, and the causative gene is located between Xq21.33 and Xq23. X-linked syndromic intellectual disability