nervous system disorder acquired metabolic disease non-familial hypertrophic cardiomyopathy non-familial restrictive cardiomyopathy amyloidosis AL amyloidosis https://github.com/monarch-initiative/mondo/issues/6752 NCIT:C158963 NANDO:1200211 MESH:C531616 AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ. primary amyloidosis Light chain amyloidosis primary systemic AL amyloidosis UMLS:C0268381 GARD:0005797 DOID:0080933 Light-chain amyloidosis primary AL amyloidosis MedDRA:10036673 Orphanet:85443 MONDO:0019438 icd11.foundation:113043090 amyloidosis primary systemic primary systemic amyloidosis MEDGEN:75674 systemic AL amyloidsis amyloidosis AL icd11.foundation:1061366491 obsolete secondary glomerular disease