syndromic disease obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome https://github.com/monarch-initiative/mondo/issues/6651 https://github.com/monarch-initiative/mondo/issues/6878 https://www.malacards.org/card/obesity_colitis_hypothyroidism_cardiac_hypertrophy_developmental_delay_syndrome This term's classification was reviewed in the context of the Strategic Refinement project (2023) and was determined to be excluded from the 'endocrine system disorder' (MONDO:0005151) ontology branch (https://orcid.org/0000-0001-9310-0163) MEDGEN:928548 UMLS:C4302879 SCTID:722051004 MONDO:0019506 Orphanet:88643 GARD:0019092 Obesity-colitis-hypothyroidism-cardiac hypertrophy-developmental delay syndrome is characterized by precocious obesity, congenital hypothyroidism, neonatal colitis, cardiac hypertrophy, craniosynostosis and developmental delay. It has been described in two brothers, one of whom died within the first month of life. The parents of the two children were nonconsanguineous and in good health, however, the pregnancies were complicated by a maternal HELLP syndrome (Haemolysis, Elevated Liver enzymes and Low Platelets). The mode of inheritance has not yet been clearly established.