immune complex mediated vasculitis cutaneous leukocytoclastic angiitis https://www.malacards.org/card/cutaneous_leukocytoclastic_angiitis cutaneous small vessel vasculitis Cutaneous leukocytoclastic angiitis is a small-vessel vasculitis presenting with palpable purpura and urticarial lesions which predate the purpuric lesions most frequently observed on the legs. Systemic symptoms including fever, cough, hemoptysis, sinusitis, arthralgia, arthritis, myalgia, abdominal pain, diarrhea, hematochezia, paresthesia, weakness, and hematuria may be observed. Skin biopsy reveals exudates rich in neutrophils, endothelial damage, fibrin deposition, and leukocytoclasis in postcapillary venules of small vessels. Cutaneous leukocytoclastic angiitis can be idiopathic (in up to 50% of cases) or secondary to infections, medications (such as antituberculosis medication), collagen vascular diseases, or neoplasms. NCIT:C122919 hypersensitivity angiitis UMLS:C4049638 SCTID:718217000 GARD:0007851 MONDO:0019509 Orphanet:889 cutaneous hypersensitivity vasculitis cutaneous leukocytoclastic vasculitis icd11.foundation:247535295 leukocytoclastic angiitis icd11.foundation:71458216 cutaneous small-vessel vasculitis MEDGEN:881641