realized in realized in gonadotropin secretion functioning pituitary gland adenoma functioning gonadotropic adenoma https://github.com/monarch-initiative/mondo/issues/8567 https://www.malacards.org/card/functioning_gonadotropic_adenoma gonadotroph adenoma SCTID:254960002 UMLS:C0346304 GARD:0019158 Functioning gonadotropic adenoma is a very rare pituitary tumor, macroscopically characterized by a soft, well vascularized, variable sized adenoma, with occasional areas of hemorrage or necrosis, that secretes biologically active gonadotropins. In addition to common neurological signs due to mass effect (headache and/or visual field deterioration), additional clinical manifestations include menstrual irregularities (secondary amenorrhea, oligomenorhea or severe menorrhagia), galactorrhea, infertility or ovarian hyperstimulation syndrome (in premenopausal women), testicular enlargement and, occasionally, hypogonadism (in men) and isosexual precocious puberty (in children). MONDO:0019612 Orphanet:91348 NCIT:C45915 functioning pituitary gonadotropic adenoma MEDGEN:577353