syndromic disease Sheehan syndrome https://www.malacards.org/card/sheehan_syndrome postpartum panhypopituitary syndrome UMLS:C0242342 Sheehan's syndrome DOID:9476 An uncommon cause of hypopituitarism seen after severe postpartum hemorrhaging. Prolonged hypovolemia leads to ischemic necrosis of the pituitary. Clinical signs typically present in the puerperium and include failure to begin lactation, fatigue, hypotension and eventual amenorrhea. Clinical course is usually mild, however extreme cases may progress to adrenal failure. Prognosis is most favorable when hormone replacement is initiated soon after symptom onset. MedDRA:10036297 GARD:0007630 MONDO:0019618 NCIT:C35300 icd11.foundation:421687193 SCTID:290653008 postpartum hypopituitarism Orphanet:91355 MEDGEN:116569 postpartum panhypopituitarism postpartum pituitary necrosis